Donald Trump and Joe Biden are preparing to face off next week in the first of three presidential debates, as a Supreme Court vacancy supercharges the election season and the U.S. continues to grapple with the coronavirus pandemic.

The first debate will be held at 9 p.m. Eastern on Sept. 29, and is hosted by Case Western Reserve University and the Cleveland Clinic, in the battleground state of Ohio. “Fox News Sunday” anchor Chris Wallace will moderate.

Now see:Ohio Republicans say they’re seeing suburban support for Trump in sharp decline statewide.

Trump and Biden will field questions for 90 minutes, without commercial breaks, according to the Commission on Presidential Debates.

Topics selected by Wallace are the candidates’ records, the Supreme Court, the coronavirus pandemic, the economy, race and violence in U.S. cities and the integrity of the election, the commission said.

Read:Republicans have the votes to confirm new Supreme Court justice, says Sen. Lindsey Graham.

Trump and Biden will debate twice more after Cleveland: on Oct. 15 in Miami and on Oct. 22 in Nashville.

Vice President Mike Pence and Biden’s running mate Kamala Harris will have a single debate, scheduled for Oct. 7 in Salt Lake City.

Heading into the debates, Trump lags Biden in polls of key battleground-state voters. In Ohio, Biden has a narrow lead over Trump of just over 2 percentage points, according to RealClearPolitics. Biden also led Trump in cash on hand as of Aug. 31.

The first debate will be shown on all the major networks and cable channels, as well as on platforms like YouTube.

The looming showdown for the Oval Office, comes amid newfound volatility in the stock market. The Dow Jones Industrial Average DJIA, +0.43% was swinging in and out of positive territory on Tuesday, while technology stocks, seen as resilient in the face of economic damage wrought by COVID-19, were trading higher after a vicious selloff on Monday.

Elevating the stakes of the 2020 presidential election is the death of Ruth Bader Ginsburg last week, with a replacement for the venerable Supreme Court Justice amplifying election jitters along with uncertainty over another coronavirus aid package from Congress.

Now read:Democrats score Ginsburg-related surge in donations, after Biden topped Trump last month in cash on hand.

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